Introducing SNAP: Spontaneous Nanoliposome Antigen Particles

POP Biotechnologies is focused on utilizing the versatile SNAP platform to discover, validate, and commercialize innovative vaccines ands immunotherapies for the treatment and prevention of infectious disease and chronic diseases including cancer.

The SNAP Platform for Advancing Vaccine Treatments

The POP BIO SNAP approach is a game-changer in vaccine development. By incubating His-tagged antigens with SNAP-liposomes, we can seamlessly and stably insert the antigens into the bilayer and create a His-tag membrane anchor. This innovative technology addresses the functional and practical limitations faced by traditional vaccine development methods, paving the way for more effective and efficient vaccines.

The SNAP Technology

How the SNAP Approach Works so Effectively

1

His-tagged proteins are commonly used to facilitate antigen purification

2

The unique composition of CoPoP enables seamless binding of his-tagged proteins (or peptides)

3

Resulting in stable potent nanoparticle vaccines with simple incubation

The SNAP Approach -
Form Multivalent Particles with Ease

We can effectively do this with multiple antigens (multiplexing).
The result is a liposome that’s more similar to the virus, fueling a more complete immune response.

Protein & Virus-Like-Particle Vaccines

SNAP
Typical Competitors
Features
Time to generate vaccine candidates
Minutes
Months
Scaffold material
Liposome-display
Protein-display
Exogenous protein content
None
Substantial (e.g. scaffold >> 50% total protein)
Off-target immune response
None
Substantial
Fusion antigens/chemical conjugation
No
Yes
Use of adjuvants
Incorporated, co-delivered to APCs
Co-administered
Antigen density
Tunable
Tunable or fixed (depends on platform)
Antigen 3D spatial orientation
Uniform
Uniform or random
(depends on platform)
Cost per human dose
< $ 0.04 (SNAP component)
Depends on platform
Multivalent antigens
Simple
Challenging

Transforming Vaccine Development with Innovative Nanoparticles

Recombinant proteins and peptides offer a safe and simple method for vaccine production. However, they often fail to produce a robust immune response. The SNAP platform addresses this limitation by providing a novel nanoparticle platform that simplifies vaccine adjuvants.

Simple and Efficient Antigen Insertion Process

The SNAP approach involves incubating His-tagged antigens with SNAP-liposomes, resulting in efficient antigen insertion.

Streamlined Vaccine Development and Manufacturing

The SNAP platform simplifies the vaccine development and manufacturing process, saving time and resources.

Enhanced Immune Response and Protection

By improving immune response, the SNAP platform offers enhanced protection against diseases.

A Clear Path Toward Human Testing

The CoPoP vaccine, manufactured by POP BIO and produced at a 2.5M dose scale under GMP, includes other components that are also obtainable under GMP.

A CoPoP GLP toxicity report is accessible, and CoPoP is a component of EuCorVac-19, which underwent testing in a 280-person phase 1/2 trial. Additionally, there is a testing framework for human epitopes.

Saturday. Summer. Beautiful sunny day, so my friends and I decided to make a picnic and watch the sundown. Pretty fun and relaxed day.by Helena Lopes